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Sperm-borne miR-449b influences cleavage, epigenetic reprogramming and apoptosis of SCNT embryos in bovine

Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Mengyun, Gao, Yang, Qu, Pengxiang, Qing, Suzhu, Qiao, Fang, Zhang, Yong, Mager, Jesse, Wang, Yongsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645405/
https://ncbi.nlm.nih.gov/pubmed/29042680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13899-8
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