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Sperm-borne miR-449b influences cleavage, epigenetic reprogramming and apoptosis of SCNT embryos in bovine

Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Mengyun, Gao, Yang, Qu, Pengxiang, Qing, Suzhu, Qiao, Fang, Zhang, Yong, Mager, Jesse, Wang, Yongsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645405/
https://ncbi.nlm.nih.gov/pubmed/29042680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-13899-8
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