MYC CONTROLS HUMAN PLURIPOTENT STEM CELL FATE DECISIONS THROUGH REGULATION OF METABOLIC FLUX

As human pluripotent stem cells (hPSCs) exit pluripotency they are thought to switch from a glycolytic mode of energy generation to one more dependent on oxidative phosphorylation. Here we show that although metabolic switching occurs during early mesoderm and endoderm differentiation, high glycolyt...

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Pubblicato in:Cell Stem Cell
Autori principali: Cliff, Timothy S., Wu, Tianming, Boward, Benjamin R., Yin, Amelia, Yin, Hang, Glushka, John N., Prestegaard, James H., Dalton, Stephen
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5644510/
https://ncbi.nlm.nih.gov/pubmed/28965765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2017.08.018
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