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Direct pro-apoptotic role for NPM1 as a regulator of PIDDosome formation
Despite being frequently mutated or deregulated in acute myeloid leukemia (AML) and many other cancers, the mechanisms by which nucleophosmin (NPM1) regulates oncogenesis remain elusive. We found that NPM1 plays a direct and conserved role in DNA damage-induced assembly of the PIDDosome complex, the...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5644479/ https://ncbi.nlm.nih.gov/pubmed/29057309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1348325 |
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