An Inhibitor of PIDDosome Formation

The PIDDosome—PIDD-RAIDD-caspase-2 complex—is a proapoptotic caspase-activation platform of elusive significance. DNA damage can initiate complex assembly via ATM phosphorylation of the PIDD death domain (DD), which enables RAIDD recruitment to PIDD. In contrast, the mechanisms limiting PIDDosome fo...

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Publicat a:Mol Cell
Autors principals: Thompson, Ruth, Shah, Richa B., Liu, Peter H., Gupta, Yogesh, Ando, Kiyohiro, Aggarwal, Aneel K., Sidi, Samuel
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458193/
https://ncbi.nlm.nih.gov/pubmed/25936804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.034
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