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NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus
The PIDDosome (PIDD–RAIDD–caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD. Here we show that DNA damage induces the ass...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5461015/ https://ncbi.nlm.nih.gov/pubmed/28432080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201608095 |
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