Haplotype-based stratification of Huntington's disease

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by expansion of a CAG trinucleotide repeat in HTT, resulting in an extended polyglutamine tract in huntingtin. We and others have previously determined that the HD-causing expansion occurs on multiple different haplo...

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Опубликовано в: :Eur J Hum Genet
Главные авторы: Chao, Michael J, Gillis, Tammy, Atwal, Ranjit S, Mysore, Jayalakshmi Srinidhi, Arjomand, Jamshid, Harold, Denise, Holmans, Peter, Jones, Lesley, Orth, Michael, Myers, Richard H, Kwak, Seung, Wheeler, Vanessa C, MacDonald, Marcy E, Gusella, James F, Lee, Jong-Min
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643960/
https://ncbi.nlm.nih.gov/pubmed/28832564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2017.125
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