NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and matur...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Wang, Jianrong, He, Nanhai, Zhang, Na, Quan, Dexian, Zhang, Shuo, Zhang, Caroline, Yu, Ruth T., Atkins, Annette R., Zhu, Ruihong, Yang, Chunhui, Cui, Ying, Liddle, Christopher, Downes, Michael, Xiao, Hui, Zheng, Ye, Auwerx, Johan, Evans, Ronald M., Leng, Qibin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643384/
https://ncbi.nlm.nih.gov/pubmed/29038463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00931-8
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge