NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection

Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while positive selection ensures the survival and matur...

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Publicat a:Nat Commun
Autors principals: Wang, Jianrong, He, Nanhai, Zhang, Na, Quan, Dexian, Zhang, Shuo, Zhang, Caroline, Yu, Ruth T., Atkins, Annette R., Zhu, Ruihong, Yang, Chunhui, Cui, Ying, Liddle, Christopher, Downes, Michael, Xiao, Hui, Zheng, Ye, Auwerx, Johan, Evans, Ronald M., Leng, Qibin
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643384/
https://ncbi.nlm.nih.gov/pubmed/29038463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00931-8
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