A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

Disruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both residing in subcellular compartments including the mitochondrial electron tr...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Elkis, Yoav, Cohen, Moshe, Yaffe, Etai, Satmary-Tusk, Shirly, Feldman, Tal, Hikri, Elad, Nyska, Abraham, Feiglin, Ariel, Ofran, Yanay, Shpungin, Sally, Nir, Uri
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643328/
https://ncbi.nlm.nih.gov/pubmed/29038547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00832-w
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