A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells

Disruption of the reprogrammed energy management system of malignant cells is a prioritized goal of targeted cancer therapy. Two regulators of this system are the Fer kinase, and its cancer cell specific variant, FerT, both residing in subcellular compartments including the mitochondrial electron tr...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Elkis, Yoav, Cohen, Moshe, Yaffe, Etai, Satmary-Tusk, Shirly, Feldman, Tal, Hikri, Elad, Nyska, Abraham, Feiglin, Ariel, Ofran, Yanay, Shpungin, Sally, Nir, Uri
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643328/
https://ncbi.nlm.nih.gov/pubmed/29038547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00832-w
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