PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

EGFR signaling is implicated in NF-κB activation. However, the concrete mechanisms by which the core transducer of NF-κB signaling pathway, RelA/p65 is regulated under EGFR activation remains to be further clarified. Here, we show that EGF stimulation induces PKCε-dependent phosphorylation of migrat...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Tao, Li, Jingjie, Xu, Meidong, Zhao, Qin, Hou, Yingyong, Yao, Liqing, Zhong, Yunshi, Chou, Ping-Chieh, Zhang, Wei, Zhou, Pinghong, Jiang, Yuhui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643311/
https://ncbi.nlm.nih.gov/pubmed/29038521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01024-2
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