Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate close to 40%, but for which no vaccines are available. Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian aden...

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Publicat a:NPJ Vaccines
Autors principals: Munster, Vincent J., Wells, Daniel, Lambe, Teresa, Wright, Daniel, Fischer, Robert J., Bushmaker, Trenton, Saturday, Greg, van Doremalen, Neeltje, Gilbert, Sarah C., de Wit, Emmie, Warimwe, George M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643297/
https://ncbi.nlm.nih.gov/pubmed/29263883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-017-0029-1
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