Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate close to 40%, but for which no vaccines are available. Here, we evaluated the utility of ChAdOx1, a promising replication-deficient simian aden...

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Detalhes bibliográficos
Publicado no:NPJ Vaccines
Main Authors: Munster, Vincent J., Wells, Daniel, Lambe, Teresa, Wright, Daniel, Fischer, Robert J., Bushmaker, Trenton, Saturday, Greg, van Doremalen, Neeltje, Gilbert, Sarah C., de Wit, Emmie, Warimwe, George M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643297/
https://ncbi.nlm.nih.gov/pubmed/29263883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-017-0029-1
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