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The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase
Intrinsically disordered proteins (IDPs) play key roles in signaling and regulation. Many IDPs undergo folding upon binding to their targets. We have proposed that coupled folding and binding of IDPs generally follow a dock-and-coalesce mechanism, whereby a segment of the IDP, through diffusion, doc...
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| Опубликовано в: : | FEBS J |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5643242/ https://ncbi.nlm.nih.gov/pubmed/28805312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14197 |
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