Inhibition of CUG-binding protein 1 and activation of caspases are critically involved in piperazine derivative BK10007S induced apoptosis in hepatocellular carcinoma cells

Though piperazine derivative BK10007S was known to induce apoptosis in pancreatic cancer xenograft model as a T-type CaV3.1 a1G isoform calcium channel blocker, its underlying antitumor mechanism still remains unclear so far. Thus, in the present study, the antitumor mechanism of BK10007S was elucid...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Ju-Ha, Kwon, Hee Young, Ryu, Dong Hoon, Nam, Min-Ho, Shim, Bum Sang, Kim, Jin Han, Lee, Jae Yeol, Kim, Sung-Hoon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643113/
https://ncbi.nlm.nih.gov/pubmed/29036189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186490
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