Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition

Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatme...

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Publicat a:Oncotarget
Autors principals: Cen, Juan, Zheng, Beibei, Bai, Rubing, Zhang, Li, Zhang, Feng, Zhang, Xia
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5642492/
https://ncbi.nlm.nih.gov/pubmed/29050217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17287
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