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Targeting MUC1-C suppresses polycomb repressive complex 1 in multiple myeloma
The polycomb repressive complex 1 (PRC1) includes the BMI1, RING1 and RING2 proteins. BMI1 is required for survival of multiple myeloma (MM) cells. The MUC1-C oncoprotein is aberrantly expressed by MM cells, activates MYC and is also necessary for MM cell survival. The present studies show that targ...
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| Izdano u: | Oncotarget |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Impact Journals LLC
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5642475/ https://ncbi.nlm.nih.gov/pubmed/29050200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20144 |
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