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A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction
Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism f...
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| Published in: | Structure |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5642270/ https://ncbi.nlm.nih.gov/pubmed/28978405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2017.09.011 |
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