Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner

BACKGROUND: Improving the neuronal yield from in vitro cultivated neural progenitor cells (NPCs) is an essential challenge in transplantation therapy in neurological disorders. In this regard, Ascorbic acid (AA) is widely used to expand neurogenesis from NPCs in cultures although the mechanisms of i...

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Detalles Bibliográficos
Publicado en:J Biomed Sci
Main Authors: Rharass, Tareck, Lantow, Margareta, Gbankoto, Adam, Weiss, Dieter G., Panáková, Daniela, Lucas, Stéphanie
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641995/
https://ncbi.nlm.nih.gov/pubmed/29037191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-017-0385-1
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