Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue

OBJECTIVES: Understanding how loci identified by genome wide association studies (GWAS) contribute to pathogenesis requires new mechanistic insights. Variants within CDKAL1 are strongly linked to an increased risk of developing type 2 diabetes and obesity. Investigations in mouse models have focused...

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發表在:Mol Metab
Main Authors: Palmer, Colin J., Bruckner, Raphael J., Paulo, Joao A., Kazak, Lawrence, Long, Jonathan Z., Mina, Amir I., Deng, Zhaoming, LeClair, Katherine B., Hall, Jessica A., Hong, Shangyu, Zushin, Peter-James H., Smith, Kyle L., Gygi, Steven P., Hagen, Susan, Cohen, David E., Banks, Alexander S.
格式: Artigo
語言:Inglês
出版: Elsevier 2017
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641635/
https://ncbi.nlm.nih.gov/pubmed/29031721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.07.013
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