Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue

OBJECTIVE: Non-shivering thermogenesis in brown adipose tissue (BAT) plays a central role in energy homeostasis. Thioesterase superfamily member 1 (Them1), a BAT-enriched long chain fatty acyl-CoA thioesterase, is upregulated by cold and downregulated by warm ambient temperatures. Them1(−/−) mice ex...

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Опубликовано в: :Mol Metab
Главные авторы: Okada, Kosuke, LeClair, Katherine B., Zhang, Yongzhao, Li, Yingxia, Ozdemir, Cafer, Krisko, Tibor I., Hagen, Susan J., Betensky, Rebecca A., Banks, Alexander S., Cohen, David E.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2016
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837299/
https://ncbi.nlm.nih.gov/pubmed/27110486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.02.002
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