Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L

Hepatocyte nuclear factor 1-alpha (HNF1A) is a liver-enriched transcription factor that plays a key role in many aspects of hepatic functions including detoxification processes. We examined whether HNF1A polymorphisms are associated with clinical outcomes in two independent cohorts combining 417 Eur...

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Publicado en:Front Pharmacol
Autores principales: Labriet, Adrien, De Mattia, Elena, Cecchin, Erika, Lévesque, Éric, Jonker, Derek, Couture, Félix, Buonadonna, Angela, D’Andrea, Mario, Villeneuve, Lyne, Toffoli, Giuseppe, Guillemette, Chantal
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641335/
https://ncbi.nlm.nih.gov/pubmed/29066969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00712
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