Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human

Physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD) models can contribute to animal-to-human extrapolation and therapeutic dose predictions. Buagafuran is a novel anxiolytic agent and phase I clinical trials of buagafuran have been completed. In this paper, a potentially effective dose...

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Detalles Bibliográficos
Publicado en:Front Pharmacol
Main Authors: Yang, Fen, Wang, Baolian, Liu, Zhihao, Xia, Xuejun, Wang, Weijun, Yin, Dali, Sheng, Li, Li, Yan
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641330/
https://ncbi.nlm.nih.gov/pubmed/29066968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00683
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