BRAF inhibitors amplify the pro-apoptotic activity of MEK inhibitors by inducing ER stress in NRAS-mutant melanoma

PURPOSE: NRAS mutations in malignant melanoma are associated with aggressive disease requiring rapid antitumor intervention, but there is no approved targeted therapy for this subset of patients. In clinical trials, the MEK inhibitor (MEKi) binimetinib displayed modest antitumor activity, making com...

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Foilsithe in:Clin Cancer Res
Main Authors: Niessner, Heike, Sinnberg, Tobias, Kosnopfel, Corinna, Smalley, Keiran S. M., Beck, Daniela, Praetorius, Christian, Mai, Marion, Beissert, Stefan, Kulms, Dagmar, Schaller, Martin, Garbe, Claus, Flaherty, Keith T., Westphal, Dana, Wanke, Ines, Meier, Friedegund
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2017
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641247/
https://ncbi.nlm.nih.gov/pubmed/28724666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0098
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