5-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway

Studies have shown that peroxisome proliferator-activated receptor γ (PPAR γ) is down-regulated in pulmonary vascular lesions of patients with pulmonary hypertension (PH) and animal models of PH. Yet, the detailed molecular mechanisms underlying this alteration are not fully defined; the aim of this...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Ke, Rui, Xie, Xinming, Li, Shaojun, Pan, Yilin, Wang, Jian, Yan, Xin, Zang, Weijin, Gao, Li, Li, Manxiang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641178/
https://ncbi.nlm.nih.gov/pubmed/29069835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.20582
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