Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA), s...

全面介紹

Na minha lista:
書目詳細資料
發表在:J Virol
Main Authors: Eyer, Ludek, Kondo, Hirofumi, Zouharova, Darina, Hirano, Minato, Valdés, James J., Muto, Memi, Kastl, Tomas, Kobayashi, Shintaro, Haviernik, Jan, Igarashi, Manabu, Kariwa, Hiroaki, Vaculovicova, Marketa, Cerny, Jiri, Kizek, Rene, Kröger, Andrea, Lienenklaus, Stefan, Dejmek, Milan, Nencka, Radim, Palus, Martin, Salat, Jiri, De Clercq, Erik, Yoshii, Kentaro, Ruzek, Daniel
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2017
主題:
Vaccines and Antiviral Agents
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640847/
https://ncbi.nlm.nih.gov/pubmed/28814513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-17
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

相似書籍