Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA), s...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Eyer, Ludek, Kondo, Hirofumi, Zouharova, Darina, Hirano, Minato, Valdés, James J., Muto, Memi, Kastl, Tomas, Kobayashi, Shintaro, Haviernik, Jan, Igarashi, Manabu, Kariwa, Hiroaki, Vaculovicova, Marketa, Cerny, Jiri, Kizek, Rene, Kröger, Andrea, Lienenklaus, Stefan, Dejmek, Milan, Nencka, Radim, Palus, Martin, Salat, Jiri, De Clercq, Erik, Yoshii, Kentaro, Ruzek, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2017
Pynciau:
Vaccines and Antiviral Agents
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640847/
https://ncbi.nlm.nih.gov/pubmed/28814513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-17
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