Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA), s...

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Publicado en:J Virol
Autores principales: Eyer, Ludek, Kondo, Hirofumi, Zouharova, Darina, Hirano, Minato, Valdés, James J., Muto, Memi, Kastl, Tomas, Kobayashi, Shintaro, Haviernik, Jan, Igarashi, Manabu, Kariwa, Hiroaki, Vaculovicova, Marketa, Cerny, Jiri, Kizek, Rene, Kröger, Andrea, Lienenklaus, Stefan, Dejmek, Milan, Nencka, Radim, Palus, Martin, Salat, Jiri, De Clercq, Erik, Yoshii, Kentaro, Ruzek, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2017
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640847/
https://ncbi.nlm.nih.gov/pubmed/28814513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-17
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