Escape of Tick-Borne Flavivirus from 2′-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness

Tick-borne encephalitis virus (TBEV) causes a severe and potentially fatal neuroinfection in humans. Despite its high medical relevance, no specific antiviral therapy is currently available. Here we demonstrate that treatment with a nucleoside analog, 7-deaza-2′-C-methyladenosine (7-deaza-2′-CMA), s...

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Dettagli Bibliografici
Pubblicato in:J Virol
Autori principali: Eyer, Ludek, Kondo, Hirofumi, Zouharova, Darina, Hirano, Minato, Valdés, James J., Muto, Memi, Kastl, Tomas, Kobayashi, Shintaro, Haviernik, Jan, Igarashi, Manabu, Kariwa, Hiroaki, Vaculovicova, Marketa, Cerny, Jiri, Kizek, Rene, Kröger, Andrea, Lienenklaus, Stefan, Dejmek, Milan, Nencka, Radim, Palus, Martin, Salat, Jiri, De Clercq, Erik, Yoshii, Kentaro, Ruzek, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640847/
https://ncbi.nlm.nih.gov/pubmed/28814513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01028-17
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