CCR7 modulates the generation of thymic regulatory T cells by altering the composition of the thymic dendritic cell compartment

Upon recognition of auto-antigens, thymocytes are negatively selected or diverted to a regulatory T cell (Treg) fate. CCR7 is required for negative selection of auto-reactive thymocytes in the thymic medulla. Here we describe an unanticipated contribution of CCR7 to intrathymic Treg generation. Ccr7...

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Publicado en:Cell Rep
Main Authors: Hu, Zicheng, Li, Yu, Van Nieuwenhuijze, Annemarie, Selden, Hilary J., Jarrett, Angela M., Sorace, Anna G., Yankeelov, Thomas E., Liston, Adrian, Ehrlich, Lauren I. R.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639943/
https://ncbi.nlm.nih.gov/pubmed/28978470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.016
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