Microprocessor recruitment to elongating RNA Polymerase II is required for differential expression of microRNAs

The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor’s diff...

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Publicado en:Cell Rep
Autores principales: Church, Victoria A., Pressman, Sigal, Isaji, Mamiko, Truscott, Mary, Cizmecioglu, Nihal Terzi, Buratowski, Stephen, Frolov, Maxim V., Carthew, Richard W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639929/
https://ncbi.nlm.nih.gov/pubmed/28954229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.010
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