Microprocessor recruitment to elongating RNA Polymerase II is required for differential expression of microRNAs

The cellular abundance of mature microRNAs (miRNAs) is dictated by the efficiency of nuclear processing of primary miRNA transcripts (pri-miRNAs) into pre-miRNA intermediates. The Microprocessor complex of Drosha and DGCR8 carries this out, but it has been unclear what controls Microprocessor’s diff...

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Pubblicato in:Cell Rep
Autori principali: Church, Victoria A., Pressman, Sigal, Isaji, Mamiko, Truscott, Mary, Cizmecioglu, Nihal Terzi, Buratowski, Stephen, Frolov, Maxim V., Carthew, Richard W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639929/
https://ncbi.nlm.nih.gov/pubmed/28954229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.010
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