A Macrocyclic Agouti-Related Protein/[Nle4, DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Sub-nanomolar Melanocortin Receptor Ligands

Antzeko izenburuak

• Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor
  nork: Ericson, Mark D., et al.
  Argitaratua: (2017)
• Synergistic Multi-Residue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists
  nork: Fleming, Katlyn A., et al.
  Argitaratua: (2018)
• Arg-Phe-Phe D-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xaa-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles
  nork: Ericson, Mark D., et al.
  Argitaratua: (2018)
• A Fragment of the Escherichia coli ClpB Heat-Shock Protein is a Micromolar Melanocortin 1 Receptor Agonist
  nork: Ericson, Mark D., et al.
  Argitaratua: (2015)
• A Direct In Vivo Comparison of The Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH(2) versus The Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH(2): A Bivalent Advantage
  nork: Lensing, Cody J., et al.
  Argitaratua: (2017)