Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) is a powerful tool to identify tau-targeted therapeutics. However, such screens have been...

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Udgivet i:Stem Cell Reports
Main Authors: Wang, Chao, Ward, Michael E., Chen, Robert, Liu, Kai, Tracy, Tara E., Chen, Xu, Xie, Min, Sohn, Peter Dongmin, Ludwig, Connor, Meyer-Franke, Anke, Karch, Celeste M., Ding, Sheng, Gan, Li
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639430/
https://ncbi.nlm.nih.gov/pubmed/28966121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.08.019
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