CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons

CRISPR/Cas9-based functional genomics have transformed our ability to elucidate mammalian cell biology. However, most previous CRISPR-based screens were conducted in cancer cell lines, rather than healthy, differentiated cells. Here, we describe a CRISPR interference (CRISPRi)-based platform for gen...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Tian, Ruilin, Gachechiladze, Mariam A., Ludwig, Connor H., Laurie, Matthew T., Hong, Jason Y., Nathaniel, Diane, Prabhu, Anika V., Fernandopulle, Michael S., Patel, Rajan, Abshari, Mehrnoosh, Ward, Michael E., Kampmann, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6813890/
https://ncbi.nlm.nih.gov/pubmed/31422865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.07.014
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