Blockage of the Epithelial-to-Mesenchymal Transition Is Required for Embryonic Stem Cell Derivation

Pluripotent cells emanate from the inner cell mass (ICM) of the blastocyst and when cultivated under optimal conditions immortalize as embryonic stem cells (ESCs). The fundamental mechanism underlying ESC derivation has, however, remained elusive. Recently, we have devised a highly efficient approac...

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Udgivet i:Stem Cell Reports
Main Authors: Totonchi, Mehdi, Hassani, Seyedeh-Nafiseh, Sharifi-Zarchi, Ali, Tapia, Natalia, Adachi, Kenjiro, Arand, Julia, Greber, Boris, Sabour, Davood, Araúzo-Bravo, Marcos J., Walter, Jörn, Pakzad, Mohammad, Gourabi, Hamid, Schöler, Hans R., Baharvand, Hossein
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5639184/
https://ncbi.nlm.nih.gov/pubmed/28919260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.08.006
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