DNA methylation regulates discrimination of enhancers from promoters through a H3K4me1-H3K4me3 seesaw mechanism

BACKGROUND: DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative...

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Udgivet i:BMC Genomics
Main Authors: Sharifi-Zarchi, Ali, Gerovska, Daniela, Adachi, Kenjiro, Totonchi, Mehdi, Pezeshk, Hamid, Taft, Ryan J., Schöler, Hans R., Chitsaz, Hamidreza, Sadeghi, Mehdi, Baharvand, Hossein, Araúzo-Bravo, Marcos J.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5727985/
https://ncbi.nlm.nih.gov/pubmed/29233090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-017-4353-7
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