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MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis

MCPH1 gene, mutated in primary microcephaly, regulates cell progression into mitosis. While this role has been extensively investigated in the context of DNA damage, its function during unperturbed cell cycles has been given less attention. Here we have analyzed the dynamics of chromosome condensati...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Arroyo, M., Kuriyama, R., Trimborn, M., Keifenheim, D., Cañuelo, A., Sánchez, A., Clarke, D. J., Marchal, J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638862/
https://ncbi.nlm.nih.gov/pubmed/29026105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12793-7
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