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Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab Library
We constructed a large naïve human Fab library (3 × 10(10) colonies) from the lymphocytes of 809 human donors, assessed available diversities of the heavy-chain variable (VH) and κ light-chain variable (VK) domain repertoires, and validated the library by selecting Fabs against 10 therapeutically re...
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| Publicado no: | Mol Cells |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Korean Society for Molecular and Cellular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5638773/ https://ncbi.nlm.nih.gov/pubmed/28927259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14348/molcells.2017.0106 |
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