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KDM6A addiction of cervical carcinoma cell lines is triggered by E7 and mediated by p21(CIP1) suppression of replication stress

Expression of E7 proteins encoded by carcinogenic, high-risk human papillomaviruses (HPVs) triggers increased expression of the histone H3 lysine 27 demethylase KDM6A. KDM6A expression is necessary for survival of high-risk HPV E7 expressing cells, including several cervical cancer lines. Here we sh...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Soto, David R., Barton, Christopher, Munger, Karl, McLaughlin-Drubin, Margaret E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638616/
https://ncbi.nlm.nih.gov/pubmed/28968467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006661
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