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Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming

Despite the availability of vaccines, human papillomavirus (HPV) infections remain a cause of significant cancer morbidity and mortality. We have previously shown that HPV16 E7 associates with and diminishes E2F6-containing polycomb repressive complexes. Here, we show that repressive trimethyl marks...

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Detalhes bibliográficos
Main Authors: McLaughlin-Drubin, Margaret E., Crum, Christopher P., Münger, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033314/
https://ncbi.nlm.nih.gov/pubmed/21245294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009933108
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