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Ruthenium‐Catalyzed Azide–Thioalkyne Cycloadditions in Aqueous Media: A Mild, Orthogonal, and Biocompatible Chemical Ligation

The development of efficient metal‐promoted bioorthogonal ligations remains as a major scientific challenge. Demonstrated herein is that azides undergo efficient and regioselective room‐temperature annulations with thioalkynes in aqueous milieu when treated with catalytic amounts of a suitable ruthe...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Destito, Paolo, Couceiro, José R., Faustino, Hélio, López, Fernando, Mascareñas, José L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5638077/
https://ncbi.nlm.nih.gov/pubmed/28685950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201705006
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