RadH: A Versatile Halogenase for Integration into Synthetic Pathways

Flavin‐dependent halogenases are useful enzymes for providing halogenated molecules with improved biological activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromatic scaffolds. Site...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637929/
https://ncbi.nlm.nih.gov/pubmed/28722773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706342
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