RadH: A Versatile Halogenase for Integration into Synthetic Pathways

Flavin‐dependent halogenases are useful enzymes for providing halogenated molecules with improved biological activity, or intermediates for synthetic derivatization. We demonstrate how the fungal halogenase RadH can be used to regioselectively halogenate a range of bioactive aromatic scaffolds. Site...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Menon, Binuraj R. K., Brandenburger, Eileen, Sharif, Humera H., Klemstein, Ulrike, Shepherd, Sarah A., Greaney, Michael F., Micklefield, Jason
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637929/
https://ncbi.nlm.nih.gov/pubmed/28722773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201706342
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