Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics

Hypoxia is associated with aggressive phenotype and poor prognosis in prostate cancer (PCa) patients suggesting that PCa growth and progression could be controlled via targeting hypoxia-induced signaling and biological effects. Here, we analyzed silibinin (a natural flavonoid) efficacy to target cel...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Carcinog
Auteurs principaux: Deep, Gagan, Kumar, Rahul, Nambiar, Dhanya K., Jain, Anil K., Ramteke, Anand M., Serkova, Natalie J., Agarwal, Chapla, Agarwal, Rajesh
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637733/
https://ncbi.nlm.nih.gov/pubmed/27533043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22537
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