Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

Hypoxia is an independent prognostic indicator of poor outcome in several malignancies. However, precise mechanism through which hypoxia promotes disease aggressiveness is still unclear. Here, we report that under hypoxia (1% O(2)), human prostate cancer (PCA) cells, and extracellular vesicles (EVs)...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Schlaepfer, Isabel R., Nambiar, Dhanya K., Ramteke, Anand, Kumar, Rahul, Dhar, Deepanshi, Agarwal, Chapla, Bergman, Bryan, Graner, Michael, Maroni, Paul, Singh, Rana P., Agarwal, Rajesh, Deep, Gagan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673203/
https://ncbi.nlm.nih.gov/pubmed/26087400
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