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Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

Hypoxia is an independent prognostic indicator of poor outcome in several malignancies. However, precise mechanism through which hypoxia promotes disease aggressiveness is still unclear. Here, we report that under hypoxia (1% O(2)), human prostate cancer (PCA) cells, and extracellular vesicles (EVs)...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Schlaepfer, Isabel R., Nambiar, Dhanya K., Ramteke, Anand, Kumar, Rahul, Dhar, Deepanshi, Agarwal, Chapla, Bergman, Bryan, Graner, Michael, Maroni, Paul, Singh, Rana P., Agarwal, Rajesh, Deep, Gagan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673203/
https://ncbi.nlm.nih.gov/pubmed/26087400
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