HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from AL...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Guo, Wenting, Naujock, Maximilian, Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Boon, Ruben, Ordovás, Laura, Patel, Abdulsamie, Welters, Marc, Vanwelden, Thomas, Geens, Natasja, Tricot, Tine, Benoy, Veronick, Steyaert, Jolien, Lefebvre-Omar, Cynthia, Boesmans, Werend, Jarpe, Matthew, Sterneckert, Jared, Wegner, Florian, Petri, Susanne, Bohl, Delphine, Vanden Berghe, Pieter, Robberecht, Wim, Van Damme, Philip, Verfaillie, Catherine, Van Den Bosch, Ludo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636840/
https://ncbi.nlm.nih.gov/pubmed/29021520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00911-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados