HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from AL...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Guo, Wenting, Naujock, Maximilian, Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Boon, Ruben, Ordovás, Laura, Patel, Abdulsamie, Welters, Marc, Vanwelden, Thomas, Geens, Natasja, Tricot, Tine, Benoy, Veronick, Steyaert, Jolien, Lefebvre-Omar, Cynthia, Boesmans, Werend, Jarpe, Matthew, Sterneckert, Jared, Wegner, Florian, Petri, Susanne, Bohl, Delphine, Vanden Berghe, Pieter, Robberecht, Wim, Van Damme, Philip, Verfaillie, Catherine, Van Den Bosch, Ludo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636840/
https://ncbi.nlm.nih.gov/pubmed/29021520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00911-y
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