HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from AL...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Guo, Wenting, Naujock, Maximilian, Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Boon, Ruben, Ordovás, Laura, Patel, Abdulsamie, Welters, Marc, Vanwelden, Thomas, Geens, Natasja, Tricot, Tine, Benoy, Veronick, Steyaert, Jolien, Lefebvre-Omar, Cynthia, Boesmans, Werend, Jarpe, Matthew, Sterneckert, Jared, Wegner, Florian, Petri, Susanne, Bohl, Delphine, Vanden Berghe, Pieter, Robberecht, Wim, Van Damme, Philip, Verfaillie, Catherine, Van Den Bosch, Ludo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636840/
https://ncbi.nlm.nih.gov/pubmed/29021520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00911-y
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