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Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses
IFN-γ-producing cytotoxic T lymphocytes are essential for host defense against viral infection and cancer. Here we show that the RNA-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+) T-cell production of IFN-γ in vivo. When activated in vitro, however, IFN-γ production by naive wild ty...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5636828/ https://ncbi.nlm.nih.gov/pubmed/29021521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00892-y |
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