High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center

High-fidelity DNA replication depends on a proofreading 3′–5′ exonuclease that is associated with the replicative DNA polymerase. The replicative DNA polymerase DnaE1 from the major pathogen Mycobacterium tuberculosis (Mtb) uses its intrinsic PHP-exonuclease that is distinct from the canonical DEDD...

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Udgivet i:Nat Commun
Main Authors: Baños-Mateos, Soledad, van Roon, Anne-Marie M., Lang, Ulla F., Maslen, Sarah L., Skehel, J. Mark, Lamers, Meindert H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636811/
https://ncbi.nlm.nih.gov/pubmed/29021523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00886-w
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